通过甲基转移酶导向的活化基团转移（mTAG）对DNA进行靶向标记。 - Suppr

Suppr

超能文献

Targeted labeling of DNA by methyltransferase-directed transfer of activated groups (mTAG).

作者信息

Lukinavicius Grazvydas, Lapiene Vidmantas, Stasevskij Zdislav, Dalhoff Christian, Weinhold Elmar, Klimasauskas Saulius

机构信息

Laboratory of Biological DNA Modification, Institute of Biotechnology, Graiciuno 8, LT-02241 Vilnius, Lithuania.

出版信息

J Am Chem Soc. 2007 Mar 14;129(10):2758-9. doi: 10.1021/ja0691876. Epub 2007 Feb 20.

DOI:10.1021/ja0691876

PMID:17309265

Abstract

摘要

相似文献

Targeted labeling of DNA by methyltransferase-directed transfer of activated groups (mTAG).

J Am Chem Soc. 2007 Mar 14;129(10):2758-9. doi: 10.1021/ja0691876. Epub 2007 Feb 20.

Direct transfer of extended groups from synthetic cofactors by DNA methyltransferases.

Nat Chem Biol. 2006 Jan;2(1):31-2. doi: 10.1038/nchembio754. Epub 2005 Nov 27.

Design, synthesis, and preliminary biological evaluation of a DNA methyltransferase-directed alkylating agent.

Chembiochem. 2006 Feb;7(2):243-5. doi: 10.1002/cbic.200500362.

The use of prokaryotic DNA methyltransferases as experimental and analytical tools in modern biology.

Anal Biochem. 2005 Mar 1;338(1):1-11. doi: 10.1016/j.ab.2004.02.048.

DNA methyltransferases (EC 2.1.1.72 and EC 2.1.1.73).

Methods Mol Biol. 1993;16:201-11. doi: 10.1385/0-89603-234-5:201.

Sequence-specific labeling of nucleic acids and proteins with methyltransferases and cofactor analogues.

J Vis Exp. 2014 Nov 22(93):e52014. doi: 10.3791/52014.

DNA methyltransferase-moderated click chemistry.

Org Lett. 2005 May 26;7(11):2141-4. doi: 10.1021/ol0504749.

Synthesis of S-adenosyl-L-methionine analogs and their use for sequence-specific transalkylation of DNA by methyltransferases.

Nat Protoc. 2006;1(4):1879-86. doi: 10.1038/nprot.2006.253.

Role of histidine residues in EcoP15I DNA methyltransferase activity as probed by chemical modification and site-directed mutagenesis.

Biochem J. 2008 Mar 15;410(3):543-53. doi: 10.1042/BJ20070900.

In vivo site-specific DNA methylation with a designed sequence-enabled DNA methylase.

J Am Chem Soc. 2007 Jul 18;129(28):8676-7. doi: 10.1021/ja0705588. Epub 2007 Jun 21.

引用本文的文献

Selective chemical tracking of DNA methylomes in live cells.

Epigenomics. 2025 Jun;17(9):575-577. doi: 10.1080/17501911.2025.2500914. Epub 2025 May 6.

Engineered Methionine Adenosyltransferase Cascades for Metabolic Labeling of Individual DNA Methylomes in Live Cells.

J Am Chem Soc. 2024 Jul 10;146(27):18722-18729. doi: 10.1021/jacs.4c06529. Epub 2024 Jun 29.

Ribozyme for stabilized SAM analogue modifies RNA in cells.

Nat Chem. 2023 Nov;15(11):1486-1487. doi: 10.1038/s41557-023-01354-3.

Post-synthetic benzylation of the mRNA 5' cap enzymatic cascade reactions.

Chem Sci. 2023 Sep 18;14(39):10962-10970. doi: 10.1039/d3sc03822j. eCollection 2023 Oct 11.

Site-Specific Covalent Labeling of DNA Substrates by an RNA Transglycosylase.

J Am Chem Soc. 2023 Apr 12;145(14):8099-8106. doi: 10.1021/jacs.3c00861. Epub 2023 Mar 29.

DNA Labeling Using DNA Methyltransferases.

Adv Exp Med Biol. 2022;1389:535-562. doi: 10.1007/978-3-031-11454-0_19.

Analogs of -Adenosyl--Methionine in Studies of Methyltransferases.

Mol Biol. 2022;56(2):229-250. doi: 10.1134/S002689332202011X. Epub 2022 Apr 14.

Chemical biology and medicinal chemistry of RNA methyltransferases.

Nucleic Acids Res. 2022 May 6;50(8):4216-4245. doi: 10.1093/nar/gkac224.

Functionalised Cofactor Mimics for Interactome Discovery and Beyond.

Angew Chem Int Ed Engl. 2022 Jul 18;61(29):e202201136. doi: 10.1002/anie.202201136. Epub 2022 May 31.

Selective chemical tracking of Dnmt1 catalytic activity in live cells.

Mol Cell. 2022 Mar 3;82(5):1053-1065.e8. doi: 10.1016/j.molcel.2022.02.008.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型，支持多种主流文档格式。

立即体验

Targeted labeling of DNA by methyltransferase-directed transfer of activated groups (mTAG).

作者信息

Lukinavicius Grazvydas, Lapiene Vidmantas, Stasevskij Zdislav, Dalhoff Christian, Weinhold Elmar, Klimasauskas Saulius

机构信息

Laboratory of Biological DNA Modification, Institute of Biotechnology, Graiciuno 8, LT-02241 Vilnius, Lithuania.

出版信息

J Am Chem Soc. 2007 Mar 14;129(10):2758-9. doi: 10.1021/ja0691876. Epub 2007 Feb 20.

DOI:10.1021/ja0691876

PMID:17309265

Abstract

摘要

相似文献

Targeted labeling of DNA by methyltransferase-directed transfer of activated groups (mTAG).

J Am Chem Soc. 2007 Mar 14;129(10):2758-9. doi: 10.1021/ja0691876. Epub 2007 Feb 20.

Direct transfer of extended groups from synthetic cofactors by DNA methyltransferases.

Nat Chem Biol. 2006 Jan;2(1):31-2. doi: 10.1038/nchembio754. Epub 2005 Nov 27.

Design, synthesis, and preliminary biological evaluation of a DNA methyltransferase-directed alkylating agent.

Chembiochem. 2006 Feb;7(2):243-5. doi: 10.1002/cbic.200500362.

The use of prokaryotic DNA methyltransferases as experimental and analytical tools in modern biology.

Anal Biochem. 2005 Mar 1;338(1):1-11. doi: 10.1016/j.ab.2004.02.048.

DNA methyltransferases (EC 2.1.1.72 and EC 2.1.1.73).

Methods Mol Biol. 1993;16:201-11. doi: 10.1385/0-89603-234-5:201.

Sequence-specific labeling of nucleic acids and proteins with methyltransferases and cofactor analogues.

J Vis Exp. 2014 Nov 22(93):e52014. doi: 10.3791/52014.

DNA methyltransferase-moderated click chemistry.

Org Lett. 2005 May 26;7(11):2141-4. doi: 10.1021/ol0504749.

Synthesis of S-adenosyl-L-methionine analogs and their use for sequence-specific transalkylation of DNA by methyltransferases.

Nat Protoc. 2006;1(4):1879-86. doi: 10.1038/nprot.2006.253.

Role of histidine residues in EcoP15I DNA methyltransferase activity as probed by chemical modification and site-directed mutagenesis.

Biochem J. 2008 Mar 15;410(3):543-53. doi: 10.1042/BJ20070900.

In vivo site-specific DNA methylation with a designed sequence-enabled DNA methylase.

J Am Chem Soc. 2007 Jul 18;129(28):8676-7. doi: 10.1021/ja0705588. Epub 2007 Jun 21.

引用本文的文献

Selective chemical tracking of DNA methylomes in live cells.

Epigenomics. 2025 Jun;17(9):575-577. doi: 10.1080/17501911.2025.2500914. Epub 2025 May 6.

Engineered Methionine Adenosyltransferase Cascades for Metabolic Labeling of Individual DNA Methylomes in Live Cells.

J Am Chem Soc. 2024 Jul 10;146(27):18722-18729. doi: 10.1021/jacs.4c06529. Epub 2024 Jun 29.

Ribozyme for stabilized SAM analogue modifies RNA in cells.

Nat Chem. 2023 Nov;15(11):1486-1487. doi: 10.1038/s41557-023-01354-3.

Post-synthetic benzylation of the mRNA 5' cap enzymatic cascade reactions.

Chem Sci. 2023 Sep 18;14(39):10962-10970. doi: 10.1039/d3sc03822j. eCollection 2023 Oct 11.

Site-Specific Covalent Labeling of DNA Substrates by an RNA Transglycosylase.

J Am Chem Soc. 2023 Apr 12;145(14):8099-8106. doi: 10.1021/jacs.3c00861. Epub 2023 Mar 29.

DNA Labeling Using DNA Methyltransferases.

Adv Exp Med Biol. 2022;1389:535-562. doi: 10.1007/978-3-031-11454-0_19.

Analogs of -Adenosyl--Methionine in Studies of Methyltransferases.

Mol Biol. 2022;56(2):229-250. doi: 10.1134/S002689332202011X. Epub 2022 Apr 14.

Chemical biology and medicinal chemistry of RNA methyltransferases.

Nucleic Acids Res. 2022 May 6;50(8):4216-4245. doi: 10.1093/nar/gkac224.

Functionalised Cofactor Mimics for Interactome Discovery and Beyond.

Angew Chem Int Ed Engl. 2022 Jul 18;61(29):e202201136. doi: 10.1002/anie.202201136. Epub 2022 May 31.

Selective chemical tracking of Dnmt1 catalytic activity in live cells.

Mol Cell. 2022 Mar 3;82(5):1053-1065.e8. doi: 10.1016/j.molcel.2022.02.008.