配体加速铟（III）催化醛与2-甲基-3-丁炔-2-醇（作为乙炔等效供体）的不对称炔基化反应。

Ligand accelerated indium(III)-catalyzed asymmetric alkynylation of aldehydes with 2-methyl-3-butyn-2-ol as an ethyne equivalent donor.

作者信息

Harada Shinji, Takita Ryo, Ohshima Takashi, Matsunaga Shigeki, Shibasaki Masakatsu

机构信息

Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113-0033, Japan.

出版信息

Chem Commun (Camb). 2007 Mar 7(9):948-50. doi: 10.1039/b614958h. Epub 2006 Dec 1.

DOI:10.1039/b614958h

PMID:17311130

Abstract

Indium(III)-catalyzed asymmetric alkynylation of aryl, heteroaryl, alkyl and alkenyl aldehydes with 2-methyl-3-butyn-2-ol as an ethyne equivalent donor was realized, and products were obtained in moderate to good yields (up to 97%) and high enantioselectivities (up to 99% ee) using 2-10 mol% of catalyst.

摘要

实现了铟（III）催化的芳基、杂芳基、烷基和烯基醛与2-甲基-3-丁炔-2-醇（作为乙炔等价物供体）的不对称炔基化反应，使用2 - 10 mol%的催化剂，产物的收率为中等至良好（高达97%），对映选择性高（高达99% ee）。