铟（III）/联萘酚配合物催化的醛的不对称炔基化反应
Asymmetric alkynylation of aldehydes catalyzed by an In(III)/BINOL complex.
作者信息
Takita Ryo, Yakura Kenichiro, Ohshima Takashi, Shibasaki Masakatsu
机构信息
Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
出版信息
J Am Chem Soc. 2005 Oct 12;127(40):13760-1. doi: 10.1021/ja053946n.
PMID:16201775
Abstract
Asymmetric alkynylation of both aromatic and aliphatic aldehydes using catalytic amounts of In(III)/BINOL is described. Dual activation of both substrates due to the "bifunctional character" of the indium(III) catalyst enables a broad range of substrate generality with high enantioselectivity (83 to >99% ee).
摘要
描述了使用催化量的铟（III）/联萘酚对芳香醛和脂肪醛进行不对称炔基化反应。由于铟（III）催化剂的“双功能特性”，两种底物的双重活化使得能够在高对映选择性（对映体过量值为83%至>99%）下实现广泛的底物通用性。
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