铜催化酰肼的乙烯基化反应。一种制备高度取代吡咯的区域选择性方法。
Copper-catalyzed vinylation of hydrazides. A regioselective entry to highly substituted pyrroles.
作者信息
Rivero Marta Rodríguez, Buchwald Stephen L
机构信息
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
出版信息
Org Lett. 2007 Mar 15;9(6):973-6. doi: 10.1021/ol062978s. Epub 2007 Feb 21.
PMID:17311390
Abstract
A modular route to highly substituted pyrroles has been developed. This transformation consists of two sequential copper-catalyzed vinylations of bis-Boc-hydrazine followed by thermal rearrangement/cyclization. A wide variety of functionalized pyrroles can be prepared in a selective manner from simple and easily accessible precursors. [reaction: see text]
摘要
已开发出一种合成高度取代吡咯的模块化方法。该转化过程包括双-Boc-肼的两步连续铜催化乙烯基化反应，随后进行热重排/环化反应。可以从简单且易于获得的前体以选择性方式制备多种功能化吡咯。[反应：见正文]
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