• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

7-甲基-8-氧代-2'-脱氧鸟苷的合成、寡核苷酸掺入及碱基对稳定性

Synthesis, oligonucleotide incorporation and base pair stability of 7-methyl-8-oxo-2'-deoxyguanosine.

作者信息

Hamm Michelle L, Billig Kelly

机构信息

Department of Chemistry, University of Richmond, Richmond, VA 23173, USA.

出版信息

Org Biomol Chem. 2006 Nov 21;4(22):4068-70. doi: 10.1039/b612597b.

DOI:10.1039/b612597b
PMID:17312959
Abstract

7-Methyl-8-oxo-2'-deoxyguanosine, an analogue of the abundant promutagen 8-oxo-2'-deoxyguanosine, was incorporated into oligonucleotides and tested for its stability in various base pairs.

摘要

7-甲基-8-氧代-2'-脱氧鸟苷是一种丰富的前诱变剂8-氧代-2'-脱氧鸟苷的类似物，它被掺入寡核苷酸中，并对其在各种碱基对中的稳定性进行了测试。

相似文献

1
Synthesis, oligonucleotide incorporation and base pair stability of 7-methyl-8-oxo-2'-deoxyguanosine.7-甲基-8-氧代-2'-脱氧鸟苷的合成、寡核苷酸掺入及碱基对稳定性
Org Biomol Chem. 2006 Nov 21;4(22):4068-70. doi: 10.1039/b612597b.
2
Oligonucleotide incorporation and base pair stability of 9-deaza-2'-deoxyguanosine, an analogue of 8-oxo-2'-deoxyguanosine.9-脱氮-2'-脱氧鸟嘌呤核苷，8-氧代-2'-脱氧鸟嘌呤核苷类似物的核苷酸掺入和碱基对稳定性。
J Org Chem. 2010 Aug 20;75(16):5661-9. doi: 10.1021/jo1010763.
3
Improved synthesis of 2'-amino-2'-deoxyguanosine and its phosphoramidite.2'-氨基-2'-脱氧鸟苷及其亚磷酰胺的合成改进
Bioorg Med Chem. 2006 Feb 1;14(3):705-13. doi: 10.1016/j.bmc.2005.08.050. Epub 2005 Oct 3.
4
Oligonucleotide incorporation of 8-thio-2'-deoxyguanosine.
Org Lett. 2004 Oct 14;6(21):3817-20. doi: 10.1021/ol0484097.
5
The C(8)-(2'-deoxy-beta-D-ribofuranoside) of 7-deazaguanine: synthesis and base pairing of oligonucleotides with unusually linked nucleobases.7-脱氮鸟嘌呤的C(8)-(2'-脱氧-β-D-呋喃核糖苷)：具有异常连接核碱基的寡核苷酸的合成与碱基配对
J Org Chem. 2001 May 18;66(10):3303-12. doi: 10.1021/jo001498q.
6
Base-pairing, tautomerism, and mismatch discrimination of 7-halogenated 7-deaza-2'-deoxyisoguanosine: oligonucleotide duplexes with parallel and antiparallel chain orientation.7-卤代-7-脱氮-2'-脱氧异鸟苷的碱基配对、互变异构及错配识别：具有平行和反平行链取向的寡核苷酸双链体
J Am Chem Soc. 2005 Jun 1;127(21):7739-51. doi: 10.1021/ja0425785.
7
Base pair stability of 8-chloro- and 8-iodo-2'-deoxyguanosine opposite 2'-deoxycytidine: implications regarding the bioactivity of 8-oxo-2'-deoxyguanosine.8-氯-2'-脱氧鸟苷和8-碘-2'-脱氧鸟苷与2'-脱氧胞苷配对时的碱基对稳定性：对8-氧代-2'-脱氧鸟苷生物活性的影响。
J Am Chem Soc. 2005 Sep 7;127(35):12220-1. doi: 10.1021/ja052578k.
8
Oligonucleotide duplexes and multistrand assemblies with 8-aza-2'-deoxyisoguanosine: a fluorescent isoG(d) shape mimic expanding the genetic alphabet and forming ionophores.含 8-氮杂-2'-脱氧鸟苷的寡核苷酸双链体和多链体组装：一种荧光异鸟苷（d）构象模拟物，可扩展遗传密码子并形成离子载体。
J Am Chem Soc. 2010 Mar 24;132(11):4016-24. doi: 10.1021/ja910020n.
9
Oligonucleotide labeling: synthesis of a new spin-labeled 2'-deoxyguanosine analogue.寡核苷酸标记：一种新型自旋标记2'-脱氧鸟苷类似物的合成
Nucleosides Nucleotides Nucleic Acids. 2000 Aug;19(8):1301-10. doi: 10.1080/15257770008033053.
10
Synthesis and properties of oligonucleotides containing 8-bromo-2'-deoxyguanosine.含8-溴-2'-脱氧鸟苷的寡核苷酸的合成与性质
Nucleosides Nucleotides Nucleic Acids. 2001 Mar;20(3):251-60. doi: 10.1081/ncn-100002085.

引用本文的文献

1
Cellular Repair of Synthetic Analogs of Oxidative DNA Damage Reveals a Key Structure-Activity Relationship of the Cancer-Associated MUTYH DNA Repair Glycosylase.氧化DNA损伤合成类似物的细胞修复揭示了癌症相关MUTYH DNA修复糖基化酶的关键构效关系。
ACS Cent Sci. 2024 Jan 26;10(2):291-301. doi: 10.1021/acscentsci.3c00784. eCollection 2024 Feb 28.
2
Structure-Activity Relationships Reveal Key Features of 8-Oxoguanine: A Mismatch Detection by the MutY Glycosylase.构效关系揭示8-氧代鸟嘌呤的关键特征：MutY糖基化酶的错配检测
ACS Chem Biol. 2017 Sep 15;12(9):2335-2344. doi: 10.1021/acschembio.7b00389. Epub 2017 Aug 8.
3
Synthesis of N2-alkyl-8-oxo-7,8-dihydro-2'-deoxyguanosine derivatives and effects of these modifications on RNA duplex stability.
N2-烷基-8-氧代-7,8-二氢-2'-脱氧鸟苷衍生物的合成及其对 RNA 双链稳定性的影响。
J Org Chem. 2011 Jan 21;76(2):720-3. doi: 10.1021/jo102187y. Epub 2010 Dec 30.