Adams Harry, Bawa Ramadan A, Jones Simon
Department of Chemistry, University of Sheffield, Dainton Building, Brook Hill, Sheffield, UK.
Org Biomol Chem. 2006 Nov 21;4(22):4206-13. doi: 10.1039/b610055d.
Chiral 9-oxazolidinyl anthracene derivatives have been prepared as single diastereoisomers by condensation of 9-anthraldehyde with the appropriate N-alkyl amino alcohol. Asymmetric Diels-Alder cycloadditions of these with N-methyl maleimide proceeds in good yield and in good diastereoselectivity, the sense of which may be controlled by judicious choice of the N-alkyl group.
通过9-蒽醛与适当的N-烷基氨基醇缩合，制备了手性9-恶唑烷基亚蒽衍生物作为单一非对映异构体。这些衍生物与N-甲基马来酰亚胺的不对称狄尔斯-阿尔德环加成反应产率良好，非对映选择性良好，其方向可通过明智地选择N-烷基来控制。
