Dwork Andrew J, Mancevski Branislav, Rosoklija Gorazd
Department of Neuroscience, New York State Psychiatric Institute, New York, NY, USA.
Int J Neuropsychopharmacol. 2007 Aug;10(4):513-36. doi: 10.1017/S1461145707007638. Epub 2007 Feb 21.
Abnormalities of cerebral white matter, oligodendrocytes, and myelin have been observed in schizophrenia with in-vivo imaging and post-mortem biochemistry. White-matter abnormalities are also frequently associated with cognitive impairment in both healthy and diseased individuals, and cognitive dysfunction is an important component of schizophrenia. While many studies have documented these associations, only a handful have examined the role of white matter in cognitive function in schizophrenia. In this paper, we explore what is known about white-matter deficits in relation to schizophrenia, cognitive deficits, or both together, in order to generate a theoretical model for the role that compromise of white matter might play in producing cognitive impairment in schizophrenia.
通过活体成像和尸检生物化学研究发现，精神分裂症患者存在脑白质、少突胶质细胞和髓鞘异常。在健康个体和患病个体中，白质异常也常与认知障碍相关，而认知功能障碍是精神分裂症的重要组成部分。虽然许多研究记录了这些关联，但只有少数研究探讨了白质在精神分裂症认知功能中的作用。在本文中，我们探讨了与精神分裂症、认知缺陷或两者相关的白质缺陷的已知情况，以便生成一个理论模型，说明白质损害在精神分裂症认知障碍产生中可能发挥的作用。
