Liu Wei-bin, Men Li-na, Xia Qiang, He Xue-tao, Huang Ru-xun
Department of Neurology, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.
Zhonghua Yi Xue Za Zhi. 2006 Dec 19;86(47):3331-4.
To evaluate the clinical value of the indices, including IgG, IgA, IgM, CD3, CD4 and CD8.
Detect CD3, CD4, CD8 by flow cytometry and detect IgG, IgA, IgM by turbidimetric method. We analyzed clinical features according to different classification of immune index, and changes of the level of these immune indices before and after treatment.
The level of IgG, IgA in patients with generalized MG was higher than that of ocular MG (P < 0.05). The ratio of CD4 to CD8 was classified into 3 groups: low (118 cases), high (60 cases), normal (68 cases). Likewise, the level of IgG, IgA, IgM was classified into 4 groups: low (156 cases), high (65 cases), disorder (31 cases), normal (67 cases). There was no statistically significance on changes of level of these immune indices before and after treatment. There was no statistically significance on clinical materials among different groups. In the low group of humoral immunity, the remission ratio of the patients with the treatment of gamma globulin was higher than that of patients without gamma globulin (95.2%, 28.8%, respectively. P < 0.01).
The immune indices of IgG, IgA, IgM, CD3, CD4, CD8 seemed to be irrelevant to severity of disease and prognosis. To some extent, these immune indices can be reference in the aspect of treatment.
评估包括IgG、IgA、IgM、CD3、CD4和CD8在内的各项指标的临床价值。
采用流式细胞术检测CD3、CD4、CD8，采用比浊法检测IgG、IgA、IgM。根据免疫指标的不同分类分析临床特征以及这些免疫指标治疗前后水平的变化。
全身型重症肌无力患者的IgG、IgA水平高于眼肌型重症肌无力患者（P<0.05）。CD4与CD8的比值分为3组：低比值组（118例）、高比值组（60例）、正常组（68例）。同样，IgG、IgA、IgM水平分为4组：低水平组（156例）、高水平组（65例）、紊乱组（31例）、正常组（67例）。这些免疫指标治疗前后水平的变化无统计学意义。不同组间临床资料无统计学意义。在体液免疫低水平组中，接受γ球蛋白治疗的患者缓解率高于未接受γ球蛋白治疗的患者（分别为95.2%、28.8%，P<0.01）。
IgG、IgA、IgM、CD3、CD4、CD8的免疫指标似乎与疾病严重程度和预后无关。在一定程度上，这些免疫指标可在治疗方面作为参考。
