Xu Xiang-Qing
Department of Neurology, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan (250011), China.
Zhongguo Zhong Xi Yi Jie He Za Zhi. 2013 Feb;33(2):177-9.
To observe the efficacy of Yiqi Qushi Recipe (YQR) in treating myasthenia gravis (MG) patients and its effects on their immune functions.
Recruited were 40 type I and II MG patients from clinics and wards of the Affiliated Hospital of Shandong University of Traditional Chinese Medicine from January 2009 to June 2011. They were randomly assigned to the treatment group (20 cases) and the control group (20 cases). Patients in the treatment group took YQR, one dose daily, while those in the control group took pyridostigmine 60 mg, three times a day. The therapeutic course consisted of eight weeks. The clinical efficacy, immunization indicators before and after treatment were observed. Meanwhile, the safety evaluation was performed.
The cured and effective rate was 75% and the total effective rate was 95% in the treatment group. They were 45% and 85% in the control group. Better results were obtained in the treatment group. Compared with the same group before treatment, IgA, IgG, and CD8 increased, IgM, CD4, and CD4/CD8 decreased in the treatment group, showing statistical difference (P < 0.05). There was no obvious change in each index of the control group after treatment (P > 0.05). Compared with the control group after treatment, IgA, IgG, and CD8 increased, CD4 and CD4/CD8 decreased in the treatment group, showing statistical difference (P < 0.05). During the course of treatment, mild diarrhea, nausea, and vomit occurred in two patients of the control group, while no adverse reaction occurred in those of the treatment group.
YQR could significantly improve clinical symptoms of MG patients, regulate their immune functions, with no obvious adverse reaction.
观察益气祛湿方（YQR）治疗重症肌无力（MG）患者的疗效及其对免疫功能的影响。
选取2009年1月至2011年6月山东中医药大学附属医院门诊及病房的40例Ⅰ型和Ⅱ型MG患者。将其随机分为治疗组（20例）和对照组（20例）。治疗组患者服用益气祛湿方，每日1剂，对照组患者服用溴吡斯的明60mg，每日3次。疗程为8周。观察临床疗效、治疗前后的免疫指标。同时进行安全性评估。
治疗组的治愈率和有效率分别为75%和95%，对照组分别为45%和85%。治疗组效果更佳。治疗组治疗后与治疗前相比，IgA、IgG、CD8升高，IgM、CD4、CD4/CD8降低，差异有统计学意义（P<0.05）。对照组治疗后各指标无明显变化（P>0.05）。治疗组治疗后与对照组相比，IgA、IgG、CD8升高，CD4、CD4/CD8降低，差异有统计学意义（P<0.05）。治疗过程中，对照组2例患者出现轻度腹泻、恶心、呕吐，治疗组未出现不良反应。
益气祛湿方可显著改善MG患者的临床症状，调节其免疫功能，且无明显不良反应。
