Carlson L A
Adv Exp Med Biol. 1975;63:185-99. doi: 10.1007/978-1-4684-3258-9_12.
Fasting serum lipoproteins (LP) were separated into VLDL, LDL and HDL by ultracentrifugation and the content of cholesterol and triglycerides analyzed in each LP class in 69 consecutive men attending a lipid clinic. The effect of using different cut off points in the definition of HLP was discussed. It was pointed out that by using lower values for the cut off points there is only an increase in the number of subjects with hyperlipoproteinemia (HLP) but also shifts in the proportions between the various types of HLP, particularly with increase in the amount of types IIB and IV. In addition to the LP abnormalities inherent in the definition of each type of HLP other LP abnormalities were observed. Thus type IIA HLP had cholesterol rich VLDL with an increased ratio cholesterol/triglycerides. The types of HLP with increased VLDL triglycerides had characteristic changes in both LDL and HDL. For LDL its triglyceride content was increased and HDL showed a lowering of its cholesterol content and a rise in triglycerides. These changes were more pronounced the higher the VLDL triglyceride concentration was. Both normo- and hyperlipoproteinemic subjects having the second pre-beta LP on agarose gel electrophoresis of the VLDL fraction called LPB (Late Pre Beta) had two characteristic LP features. VLDL had an increased cholesterol/triglyceride ratio. LDL had a raised triglyceride content. The relation of LPB to so called intermediary particles was discussed. When the SPB (Sinking Pre Beta) LP variant was present this had negligible effects on the LP composition. Type IIA was present in 14 percent of the 609 men. None had tendinous xanthomata. The LP pattern of this common type IIA was compared to the LP pattern of the uncommon type IIA where tendinous xanthomata are present, called IIA-X. Type IIA-X had much higher LDL cholesterol and in relation to the triglyceride content a more cholesterol rich LDL. Furthermore type IIA-X had lower VLDL lipids than the common type IIA, but type IIA-X was more cholesterol rich. The differences in clinical appearance as well as in quantitative and qualitative LP composition between the common type IIA and type IIA-X makes it important to separate these two types of HLP from each other.
通过超速离心法将69名连续就诊于血脂门诊的男性的空腹血清脂蛋白（LP）分离为极低密度脂蛋白（VLDL）、低密度脂蛋白（LDL）和高密度脂蛋白（HDL），并分析各LP类别中胆固醇和甘油三酯的含量。讨论了在高脂蛋白血症（HLP）定义中使用不同切点的影响。指出采用较低的切点值时，不仅高脂蛋白血症患者的数量会增加，而且各种类型HLP之间的比例也会发生变化，特别是IIB型和IV型的数量会增加。除了每种类型HLP定义中固有的LP异常外，还观察到了其他LP异常。因此，IIA型HLP的VLDL富含胆固醇，胆固醇/甘油三酯比值增加。VLDL甘油三酯增加的HLP类型在LDL和HDL中均有特征性变化。对于LDL，其甘油三酯含量增加，而HDL则表现为胆固醇含量降低和甘油三酯升高。VLDL甘油三酯浓度越高，这些变化越明显。在VLDL部分的琼脂糖凝胶电泳中出现第二条前β-LP（称为LPB，即晚期前β）的正常和高脂蛋白血症患者都有两个特征性的LP特征。VLDL的胆固醇/甘油三酯比值增加。LDL的甘油三酯含量升高。讨论了LPB与所谓中间颗粒的关系。当存在SPB（下沉前β）LP变异体时，其对LP组成的影响可忽略不计。609名男性中有14%为IIA型。无一例有肌腱黄色瘤。将这种常见IIA型的LP模式与罕见的有肌腱黄色瘤的IIA型（称为IIA-X型）的LP模式进行了比较。IIA-X型的LDL胆固醇水平高得多，相对于甘油三酯含量，其LDL富含更多胆固醇。此外，IIA-X型的VLDL脂质低于常见IIA型，但IIA-X型富含更多胆固醇。常见IIA型和IIA-X型在临床表现以及LP组成的定量和定性方面的差异使得将这两种类型的HLP区分开来很重要。
