Davis Mellar P
Harry R. Horvitz Center for Palliative Medicine, Taussig Cancer Center, The Cleveland Clinic Foundation, Ohio, USA.
J Opioid Manag. 2005 Jul-Aug;1(3):153-61. doi: 10.5055/jom.2005.0035.
Opioids are responsible for 25 percent of constipation in terminally ill patients. Patients in pain require prophylaxis to prevent opioid bowel syndrome (OBS). Laxatives are the treatment of choice, but are marginally effective. The development of quaternary opioid receptor antagonists is a step toward target-specific therapy for opioid-induced bowel dysfunction. This review will discuss the pathophysiology and management of OBS.
阿片类药物导致了25%的晚期患者便秘。疼痛患者需要进行预防以防止阿片类肠综合征（OBS）。泻药是首选治疗方法，但效果甚微。季铵类阿片受体拮抗剂的研发是朝着阿片类药物引起的肠功能障碍的靶向特异性治疗迈出的一步。本综述将讨论OBS的病理生理学和管理。
