使用坚固的碳纳米管原子力显微镜探针实现自组装生物分子系统的超分辨率成像。

Ultra-resolution imaging of a self-assembling biomolecular system using robust carbon nanotube AFM probes.

作者信息

Carnally Stewart, Barrow Katharine, Alexander Morgan R, Hayes Christopher J, Stolnik Snjezana, Tendler Saul J B, Williams Philip M, Roberts Clive J

机构信息

Laboratory of Biophysics and Surface Analysis, School of Pharmacy, The University of Nottingham, Nottingham, NG7 2RD, United Kingdom.

出版信息

Langmuir. 2007 Mar 27;23(7):3906-11. doi: 10.1021/la0626205. Epub 2007 Feb 22.

DOI:10.1021/la0626205

PMID:17315892

Abstract

Nanoscale structural features of a novel self-assembling DNA based nanostructure have been resolved. Image data is of sufficient resolution to allow molecular orientation and the effect of surface adsorption to be characterized. This has been achieved using AFM with probes employing carbon nanotubes attached via a thin film of plasma polymerized hexane. This presents the nanotube with a highly hydrophobic coating to which it can adsorb, increasing production success and probe robustness.

摘要

一种新型的基于自组装DNA的纳米结构的纳米级结构特征已得到解析。图像数据具有足够的分辨率，能够对分子取向和表面吸附效应进行表征。这是通过使用原子力显微镜（AFM）实现的，其探针采用通过等离子体聚合己烷薄膜连接的碳纳米管。这为纳米管提供了一种高度疏水的涂层，纳米管可以吸附在该涂层上，提高了生产成功率和探针的稳定性。