Haller Michael J, Shuster Jonathan J, Schatz Desmond, Melker Richard J
Division of Pediatric Endocrinology, University of Florida, Gainesville, Florida 32610, USA.
Diabetes Technol Ther. 2007 Feb;9(1):1-9. doi: 10.1089/dia.2006.0051.
The effect of temperature and humidity on the reliability of glucose monitoring systems (GMS) has not been well reported. We performed a study to determine if the effect of temperature and humidity on glucose values could be accurately predicted.
Eight GMS, including meter, strips, and glucose control solution (GCS), were placed in an environmental chamber for 50 days. Failure of the environmental chamber allowed for the serendipitous observation of the effect on glucose results of a range of temperature (54-87 degrees F) and humidity (49-100%) typically experienced by patients when performing self-monitoring of blood glucose. GCS was used to generate glucose results in triplicate for each meter daily. Temperature and humidity variations were recorded, and a linear model was generated to explain the variation in glucose results.
Both temperature and humidity had significant effects on the reliability of nearly all GMS. The effect of temperature was greater than the effect of humidity.
In this pilot study, GMS were unreliable at temperatures and humidity within the manufacturers' recommended limits. Such variations could result in clinically significant errors in diabetes management. Further studies are needed to confirm the potential inadequacies of GMS with multiple meters and real-time patient blood samples. Glucose meter manufacturers should develop systems that either are less affected by climate or adjust reported values based on ambient temperature and humidity.
温度和湿度对血糖监测系统（GMS）可靠性的影响尚未得到充分报道。我们开展了一项研究，以确定温度和湿度对血糖值的影响是否能够被准确预测。
将包括血糖仪、试纸条和葡萄糖质控液（GCS）在内的8套血糖监测系统置于环境试验箱中50天。由于环境试验箱出现故障，得以意外观察到患者在进行自我血糖监测时通常会经历的一系列温度（54 - 87华氏度）和湿度（49 - 100%）对血糖结果的影响。每天使用GCS为每台血糖仪重复测量三次血糖结果。记录温度和湿度的变化，并建立线性模型来解释血糖结果的变化。
温度和湿度对几乎所有血糖监测系统的可靠性均有显著影响。温度的影响大于湿度的影响。
在这项初步研究中，血糖监测系统在制造商推荐的温度和湿度范围内不可靠。这种变化可能导致糖尿病管理中出现具有临床意义的误差。需要进一步研究来证实使用多种血糖仪和实时患者血样时血糖监测系统可能存在的不足。血糖仪制造商应开发受气候影响较小或能根据环境温度和湿度调整报告值的系统。
