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基于微波谐振器的温度校正型流体葡萄糖传感器。

Temperature-Corrected Fluidic Glucose Sensor Based on Microwave Resonator.

机构信息

Department of Electrical and Electronic Engineering, Yonsei University, Seoul 03722, Korea.

Department of Physics Education, College of Education, Daegu University, Gyeongsan 38453, Korea.

出版信息

Sensors (Basel). 2018 Nov 9;18(11):3850. doi: 10.3390/s18113850.

DOI:10.3390/s18113850
PMID:30423976
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6263380/
Abstract

In this paper, a fluidic glucose sensor that is based on a complementary split-ring resonator (CSRR) is proposed for the microwave frequency region. The detection of glucose with different concentrations from 0 mg/dL to 400 mg/dL in a non-invasive manner is possible by introducing a fluidic system. The glucose concentration can be continuously monitored by tracking the transmission coefficient S 21 as a sensing parameter. The variation tendency in S 21 by the glucose concentration is analyzed with equivalent circuit model. In addition, to eradicate the systematic error due to temperature variation, the sensor is tested in two temperature conditions: the constant temperature condition and the time-dependent varying temperature condition. For the varying temperature condition, the temperature correction function was derived between the temperature and the variation in S 21 for DI water. By applying the fitting function to glucose solution, the subsidiary results due to temperature can be completely eliminated. As a result, the S 21 varies by 0.03 dB as the glucose concentration increases from 0 mg/dL to 400 mg/dL.

摘要

本文提出了一种基于互补分裂环谐振器(CSRR)的流体葡萄糖传感器,用于微波频率区域。通过引入流体系统,可以非侵入式地检测 0 mg/dL 至 400 mg/dL 之间不同浓度的葡萄糖。通过跟踪传输系数 S 21 作为传感参数,可以连续监测葡萄糖浓度。通过等效电路模型分析 S 21 随葡萄糖浓度的变化趋势。此外,为了消除因温度变化引起的系统误差,传感器在两种温度条件下进行测试:恒温条件和时变温度条件。对于时变温度条件,推导了 DI 水的温度和 S 21 变化之间的温度校正函数。通过将拟合函数应用于葡萄糖溶液,可以完全消除因温度引起的副效应。结果,当葡萄糖浓度从 0 mg/dL 增加到 400 mg/dL 时,S 21 变化了 0.03 dB。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d4b/6263380/14aa07725acd/sensors-18-03850-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d4b/6263380/c06d98f2b352/sensors-18-03850-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d4b/6263380/bd78631967b1/sensors-18-03850-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d4b/6263380/cfdf3271de09/sensors-18-03850-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d4b/6263380/bd8af3d702b4/sensors-18-03850-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d4b/6263380/5fb0ccc2ffbc/sensors-18-03850-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d4b/6263380/75dbd5b8558a/sensors-18-03850-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d4b/6263380/4ce0613bd1ab/sensors-18-03850-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d4b/6263380/14aa07725acd/sensors-18-03850-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d4b/6263380/c06d98f2b352/sensors-18-03850-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d4b/6263380/bd78631967b1/sensors-18-03850-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d4b/6263380/cfdf3271de09/sensors-18-03850-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d4b/6263380/bd8af3d702b4/sensors-18-03850-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d4b/6263380/5fb0ccc2ffbc/sensors-18-03850-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d4b/6263380/75dbd5b8558a/sensors-18-03850-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d4b/6263380/4ce0613bd1ab/sensors-18-03850-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d4b/6263380/14aa07725acd/sensors-18-03850-g008.jpg

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