Rashid Imran, van Reyk David M, Davies Michael J
Free Radical Group, Heart Research Institute, Sydney, NSW 2050, Australia.
FEBS Lett. 2007 Mar 6;581(5):1067-70. doi: 10.1016/j.febslet.2007.01.082. Epub 2007 Feb 7.
Glycation of low-density lipoprotein (LDL) by reactive aldehydes, such as glycolaldehyde, can result in the cellular accumulation of cholesterol in macrophages. In this study, it is shown that carnosine, or its constituent amino acids beta-alanine and l-histidine, can inhibit the modification of LDL by glycolaldehyde when present at equimolar concentrations to the modifying agent. This protective effect was accompanied by inhibition of cholesterol and cholesteryl ester accumulation in human monocyte-derived macrophages incubated with the glycated LDL. Thus, carnosine and its constituent amino acids may have therapeutic potential in preventing diabetes-induced atherosclerosis.
活性醛（如乙醇醛）对低密度脂蛋白（LDL）的糖基化作用可导致巨噬细胞内胆固醇的蓄积。本研究表明，肌肽及其组成氨基酸β-丙氨酸和L-组氨酸在与修饰剂等摩尔浓度存在时，可抑制乙醇醛对LDL的修饰。这种保护作用伴随着在用糖基化LDL孵育的人单核细胞衍生巨噬细胞中胆固醇和胆固醇酯蓄积的抑制。因此，肌肽及其组成氨基酸在预防糖尿病诱导的动脉粥样硬化方面可能具有治疗潜力。
