Bio-Nano Electronics Research Centre, Graduate School of Interdisciplinary New Science, Toyo University, Saitama, Japan.
Drug Deliv. 2021 Dec;28(1):550-568. doi: 10.1080/10717544.2021.1892241.
Atherosclerosis is Caesar's sword, which poses a huge risk to the present generation. Understanding the atherosclerotic disease cycle would allow ensuring improved diagnosis, better care, and treatment. Unfortunately, a highly effective and safe way of treating atherosclerosis in the medical community remains a continuous challenge. Conventional treatments have shown considerable success, but have some adverse effects on the human body. Natural derived medications or nutraceuticals have gained immense popularity in the treatment of atherosclerosis due to their decreased side effects and toxicity-related issues. In hindsight, the contribution of nutraceuticals in imparting enhanced clinical efficacy against atherosclerosis warrants more experimental evidence. On the other hand, nanotechnology and drug delivery systems (DDS) have revolutionized the way therapeutics are performed and researchers have been constantly exploring the positive effects that DDS brings to the field of therapeutic techniques. It could be as exciting as ever to apply nano-mediated delivery of nutraceuticals as an additional strategy to target the atherosclerotic sites boasting high therapeutic efficiency of the nutraceuticals and fewer side effects.
动脉粥样硬化是凯撒的剑，对当代人构成了巨大的风险。了解动脉粥样硬化疾病周期将有助于确保改善诊断、更好的护理和治疗。不幸的是，在医学界，一种安全有效的治疗动脉粥样硬化的方法仍然是一个持续的挑战。传统的治疗方法已经取得了相当大的成功，但对人体有一些不良影响。由于副作用和毒性相关问题的减少，天然药物或营养保健品在动脉粥样硬化的治疗中得到了广泛的关注。有鉴于此，营养保健品在增强抗动脉粥样硬化的临床疗效方面的贡献需要更多的实验证据。另一方面，纳米技术和药物传递系统（DDS）彻底改变了治疗的方式，研究人员一直在不断探索 DDS 给治疗技术领域带来的积极影响。将纳米介导的营养保健品传递作为一种额外的策略来靶向具有高营养保健品治疗效率和更少副作用的动脉粥样硬化部位，这可能像以往一样令人兴奋。
