Yokota Harumasa, Nagaoka Taiji, Mori Fumihiko, Hikichi Taiichi, Hosokawa Hiromichi, Tanaka Hiroshi, Ishida Yuichi, Suzuki Fumiaki, Yoshida Akitoshi
Department of Ophthalmology, Asahikawa Medical College, Asahikawa, Japan.
Am J Ophthalmol. 2007 Mar;143(3):531-3. doi: 10.1016/j.ajo.2006.10.046. Epub 2006 Nov 28.
To evaluate serum prorenin levels in preterm infants with or without retinopathy of prematurity (ROP).
Noncomparative retrospective case control study.
Serum prorenin levels in children with a gestational age younger than 36 weeks were measured with antibody-activating direct enzyme kinetic assay.
The mean prorenin concentrations were higher in preterm infants with ROP than in infants without ROP at every time point: from 26 to 30 weeks, 2326 +/- 334 microg/ml (mean +/- SE [standard error]) (n = 3) and 1164 +/- 234 microg/ml (n = 3), respectively (P < .05); from 31 to 35 weeks, 1760 +/- 496 microg/ml (n = 10) and 957.1 +/- 139 microg/ml (n = 25) (P < .05); from 36 to 40 weeks, 958.2 +/- 194.2 microg/ml (n = 23) and 470.1 +/- 32.6 microg/ml (n = 67) (P < .01); and from 41 to 45 weeks, 575.8 +/- 148.4 (n = 9) and 385.6 +/- 47.9 (n = 13), which is not significantly different.
Prorenin levels in preterm infants can predict which infants will develop ROP.
评估患有或未患早产儿视网膜病变（ROP）的早产儿的血清前肾素水平。
非对照回顾性病例对照研究。
采用抗体激活直接酶动力学分析法测量孕周小于36周儿童的血清前肾素水平。
在每个时间点，患有ROP的早产儿的平均前肾素浓度均高于未患ROP的婴儿：在26至30周时，分别为2326±334微克/毫升（平均值±标准误[标准误差]）（n = 3）和1164±234微克/毫升（n = 3）（P <.05）；在31至35周时，分别为1760±496微克/毫升（n = 10）和957.1±139微克/毫升（n = 25）（P <.05）；在36至40周时，分别为958.2±194.2微克/毫升（n = 23）和470.1±32.6微克/毫升（n = 67）（P <.01）；在41至45周时，分别为575.8±148.4（n = 9）和385.6±47.9（n = 13），差异无统计学意义。
早产儿的前肾素水平可预测哪些婴儿会发生ROP。
