早产儿视网膜病变中的前肾素水平。

Prorenin levels in retinopathy of prematurity.

作者信息

Yokota Harumasa, Nagaoka Taiji, Mori Fumihiko, Hikichi Taiichi, Hosokawa Hiromichi, Tanaka Hiroshi, Ishida Yuichi, Suzuki Fumiaki, Yoshida Akitoshi

机构信息

Department of Ophthalmology, Asahikawa Medical College, Asahikawa, Japan.

出版信息

Am J Ophthalmol. 2007 Mar;143(3):531-3. doi: 10.1016/j.ajo.2006.10.046. Epub 2006 Nov 28.

DOI:10.1016/j.ajo.2006.10.046

PMID:17317409

Abstract

PURPOSE

To evaluate serum prorenin levels in preterm infants with or without retinopathy of prematurity (ROP).

DESIGN

Noncomparative retrospective case control study.

METHODS

Serum prorenin levels in children with a gestational age younger than 36 weeks were measured with antibody-activating direct enzyme kinetic assay.

RESULTS

The mean prorenin concentrations were higher in preterm infants with ROP than in infants without ROP at every time point: from 26 to 30 weeks, 2326 +/- 334 microg/ml (mean +/- SE [standard error]) (n = 3) and 1164 +/- 234 microg/ml (n = 3), respectively (P < .05); from 31 to 35 weeks, 1760 +/- 496 microg/ml (n = 10) and 957.1 +/- 139 microg/ml (n = 25) (P < .05); from 36 to 40 weeks, 958.2 +/- 194.2 microg/ml (n = 23) and 470.1 +/- 32.6 microg/ml (n = 67) (P < .01); and from 41 to 45 weeks, 575.8 +/- 148.4 (n = 9) and 385.6 +/- 47.9 (n = 13), which is not significantly different.

CONCLUSIONS

Prorenin levels in preterm infants can predict which infants will develop ROP.

摘要

目的

评估患有或未患早产儿视网膜病变（ROP）的早产儿的血清前肾素水平。

设计

非对照回顾性病例对照研究。

方法

采用抗体激活直接酶动力学分析法测量孕周小于36周儿童的血清前肾素水平。

结果

在每个时间点，患有ROP的早产儿的平均前肾素浓度均高于未患ROP的婴儿：在26至30周时，分别为2326±334微克/毫升（平均值±标准误[标准误差]）（n = 3）和1164±234微克/毫升（n = 3）（P <.05）；在31至35周时，分别为1760±496微克/毫升（n = 10）和957.1±139微克/毫升（n = 25）（P <.05）；在36至40周时，分别为958.2±194.2微克/毫升（n = 23）和470.1±32.6微克/毫升（n = 67）（P <.01）；在41至45周时，分别为575.8±148.4（n = 9）和385.6±47.9（n = 13），差异无统计学意义。