Romeo M G, Tina L G, Scuderi A, Di Pietro M, Caracciolo M, Distefano G
Cattedra di Neonatologia, Università di Catania, Italia.
Pediatr Med Chir. 1994 Jan-Feb;16(1):59-62.
Retinopathy of prematurity (ROP) is a multifactorial disease where production of free radicals is a pathogenic factor. Bilirubin is regarded today as the most powerful antioxidant substance "in vitro". To test such effect "in vivo" we studied 219 premature infants, admitted to our Neonatal Intensive Case Unit from April 1991 to October 1992, evaluating their serum bilirubin levels from day two to seven and mean bilirubin level of first week for each child. We also calculated the mean rate of daily increase of bilirubin. Our results show that bilirubin parameters considered are higher in neonates which will develop ROP of every stage than in the control ones. These results therefore do not support the concept that bilirubin could have a role in the prevention of ROP.
早产儿视网膜病变（ROP）是一种多因素疾病，其中自由基的产生是一个致病因素。胆红素如今被视为“体外”最强大的抗氧化物质。为了在“体内”测试这种效果，我们研究了1991年4月至1992年10月入住我们新生儿重症监护病房的219名早产儿，评估他们从第二天到第七天的血清胆红素水平以及每个孩子第一周的平均胆红素水平。我们还计算了胆红素的每日平均升高率。我们的结果表明，在各个阶段发生ROP的新生儿中，所考虑的胆红素参数高于对照组。因此，这些结果不支持胆红素可能在预防ROP中起作用的观点。
