Han Chunhui, Chen Yi-Jen, Liu An, Schultheiss Timothy E, Wong Jeffrey Y C
Department of Radiation Physics, City of Hope National Medical Center, Duarte, CA 91010, USA.
Med Dosim. 2007 Spring;32(1):33-7. doi: 10.1016/j.meddos.2006.10.004.
This study evaluated the efficacy of using helical tomotherapy for conformal avoidance treatment of anal adenocarcinoma. We retrospectively generated step-and-shoot intensity-modulated radiotherapy (sIMRT) plans and helical tomotherapy plans for two anal cancer patients, one male and one female, who were treated by the sIMRT technique. Dose parameters for the planning target volume (PTV) and the organs-at-risk (OARs) were compared between the sIMRT and the helical tomotherapy plans. The helical tomotherapy plans showed better dose homogeneity in the PTV, better dose conformity around the PTV, and, therefore, better sparing of nearby OARs compared with the sIMRT plans. In-vivo skin dose measurements were performed during conformal avoidance helical tomotherapy treatment of an anal cancer patient to verify adequate delivery of skin dose and sparing of OARs.
本研究评估了螺旋断层放射治疗用于肛管腺癌适形回避治疗的疗效。我们回顾性地为两名分别采用静态调强放射治疗（sIMRT）技术治疗的肛管癌患者（一男一女）生成了静态调强放射治疗计划和螺旋断层放射治疗计划。比较了sIMRT计划与螺旋断层放射治疗计划中计划靶区（PTV）和危及器官（OARs）的剂量参数。与sIMRT计划相比，螺旋断层放射治疗计划在PTV中显示出更好的剂量均匀性，在PTV周围具有更好的剂量适形性，因此对附近OARs的保护更好。在一名肛管癌患者的适形回避螺旋断层放射治疗期间进行了体内皮肤剂量测量，以验证皮肤剂量的充分给予和OARs的保护情况。
