Solár P, Horváth V, Kleban J, Koval' J, Solárová Z, Kozubík A, Fedorocko P
P.J. Safárik University, Kosice, Slovak Republic.
Neoplasma. 2007;54(2):127-30.
Ovarian carcinoma is the leading cause of death among gynecological neoplasms in the world. The chemoresistance is a major obstacle in the effective treatment of ovarian and other cancers. We evaluated the effects of Hsp90 inhibitor geldanamycin (GEL) alone and in combination with cisplatin in cisplatin resistant ovarian adenocarcinoma cell line. Our results showed Akt depletion and S-phase arrest of A2780cis cells after GEL treatment. Combined exposure of A2780cis cells to GEL and cisplatin resulted in greater than additive cytotoxic effect.
卵巢癌是全球妇科肿瘤中导致死亡的主要原因。化疗耐药是卵巢癌及其他癌症有效治疗的主要障碍。我们评估了热休克蛋白90（Hsp90）抑制剂格尔德霉素（GEL）单独及与顺铂联合应用于顺铂耐药卵巢腺癌细胞系的效果。我们的结果显示，GEL处理后A2780cis细胞中Akt蛋白缺失及S期阻滞。A2780cis细胞同时暴露于GEL和顺铂导致了大于相加的细胞毒性作用。
