Lustig L R, Sciubba J, Holliday M J
Department of Otolaryngology-Head & Neck Surgery, University of California, San Francisco, California 94143-0342, USA.
J Laryngol Otol. 2007 Aug;121(8):725-35. doi: 10.1017/S0022215107006081. Epub 2007 Feb 26.
To evaluate the clinical presentation and outcomes of treatment for patients with chondrosarcomas involving the skull base and temporal bone.
Retrospective review.
Tertiary medical centre.
Cases of histologically confirmed chondrosarcoma involving the skull base and temporal bones.
Surgery.
Demographic features of presenting patients; presenting symptoms and signs; surgical approach employed; use of post-operative radiation therapy; histological grade of tumour; and interval of post-operative follow up.
Twelve patients were identified with chondrosarcomas involving the skull base, with post-operative follow up ranging from three to 33 years. The average age at presentation was 42 years. The most common presenting symptoms were diplopia, decreased visual acuity and headaches. Five of the 12 patients required multiple surgical procedures.
Patients with chondrosarcoma involving the skull base and temporal bone may present in a variety of ways. Surgical resection, even subtotal, in combination with radiation therapy, can often provide good tumour control over many years for these rare tumours.
评估累及颅底和颞骨的软骨肉瘤患者的临床表现及治疗结果。
回顾性研究。
三级医疗中心。
经组织学确诊的累及颅底和颞骨的软骨肉瘤病例。
手术。
就诊患者的人口统计学特征；就诊时的症状和体征；采用的手术入路；术后放疗的使用情况；肿瘤的组织学分级；以及术后随访时间。
确定12例累及颅底的软骨肉瘤患者，术后随访时间为3至33年。就诊时的平均年龄为42岁。最常见的就诊症状是复视、视力下降和头痛。12例患者中有5例需要多次手术。
累及颅底和颞骨的软骨肉瘤患者可能有多种表现方式。手术切除，即使是次全切除，联合放疗，通常可以对这些罕见肿瘤在多年内实现良好的肿瘤控制。
