Ago Jun, Ishikawa Takashi, Matsumoto Naotaka, Rahman Md Ashequr, Kamei Chiaki
Department of Medicinal Pharmacology, Okayama University Graduate, School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, 700-8530, Japan.
Eur J Pharmacol. 2007 Mar 29;560(1):23-8. doi: 10.1016/j.ejphar.2006.11.050. Epub 2006 Dec 1.
The present study was undertaken to investigate the spontaneous epileptiformic activity induced by antidepressants using amygdala-kindled rats. The intraperitoneal injection of imipramine and amitriptyline resulted in potent behavioral and electroencephalogram (EEG)-detected seizures in amygdala-kindled rats compared with those seen in sham rats (non-kindled rats). Almost the same findings were observed with clomipramine and maprotiline. On the other hand, paroxetine caused no or little behavioral or EEG seizures in either amygdala-kindled or sham rats, even at a dose of 50 mg/kg. In conclusion, our results indicate that epileptiformic activity induced by kindling increases the susceptibility to cyclic antidepressant-induced seizures.
