Fujii Yoko, Tanaka Takehiro, Harada Chie, Hirai Tadashi, Kamei Chiaki
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Okayama University, Tsushima-naka 1-1-1, Okayama 700-8530, Japan.
Brain Res. 2003 Nov 21;991(1-2):258-61. doi: 10.1016/j.brainres.2003.08.009.
The epileptogenic activities induced by histamine H(1) antagonists in amygdala-kindled rats were studied in comparison with activities in nonkindled rats (sham rats). Intraperitoneal injection of pyrilamine, diphenhydramine and ketotifen resulted in behavioral and electroencephalogram (EEG)-detected seizures in amygdala-kindled rats at doses which caused no or negligible seizures in sham rats. On the other hand, loratadine and cetirizine caused no behavioral or EEG seizures in either amygdala-kindled or sham rats even at a dose of 40 mg/kg. In conclusion, first-generation H(1) antagonists likely elicit epileptogenic activity in amygdala-kindled rats more potent than that in sham rats.
研究了组胺H(1)拮抗剂在杏仁核点燃大鼠中诱导的致痫活性，并与未点燃大鼠（假手术大鼠）的活性进行比较。腹腔注射吡苄明、苯海拉明和酮替芬，在杏仁核点燃大鼠中会导致行为和脑电图（EEG）检测到的癫痫发作，而在假手术大鼠中，相同剂量不会引起癫痫发作或只会引起可忽略不计的癫痫发作。另一方面，即使在剂量为40mg/kg时，氯雷他定和西替利嗪在杏仁核点燃大鼠或假手术大鼠中均未引起行为或EEG癫痫发作。总之，第一代H(1)拮抗剂在杏仁核点燃大鼠中可能比在假手术大鼠中更易引发致痫活性。
