Homann Dirk, Lewicki Hanna, Brooks David, Eberlein Jens, Mallet-Designé Valerie, Teyton Luc, Oldstone Michael B A
Barbara Davis Center, University of Colorado at Denver and Health Sciences Center, 12801 East 17th Avenue, Aurora CO, USA.
Virology. 2007 Jun 20;363(1):113-23. doi: 10.1016/j.virol.2006.12.025. Epub 2007 Feb 21.
Virus-specific CD4(+) T cells contribute to effective virus control through a multiplicity of mechanisms including direct effector functions as well as "help" for B cell and CD8(+) T cell responses. Here, we have used the lymphocytic choriomeningitis virus (LCMV) system to assess the minimal constraints of a dominant antiviral CD4(+) T cell response. We report that the core epitope derived from the LCMV glycoprotein (GP) is 11 amino acids in length and provides optimal recognition by epitope-specific CD4(+) T cells. Surprisingly, this epitope is also recognized by LCMV-specific CD8(+) T cells and thus constitutes a unique viral determinant with dual MHC class I- and II-restriction.
病毒特异性CD4(+) T细胞通过多种机制促进有效的病毒控制，这些机制包括直接效应功能以及对B细胞和CD8(+) T细胞反应的“辅助”作用。在此，我们利用淋巴细胞性脉络丛脑膜炎病毒（LCMV）系统来评估优势抗病毒CD4(+) T细胞反应的最小限制因素。我们报告称，源自LCMV糖蛋白（GP）的核心表位长度为11个氨基酸，并能被表位特异性CD4(+) T细胞进行最佳识别。令人惊讶的是，该表位也能被LCMV特异性CD8(+) T细胞识别，因此构成了一种具有独特的I类和II类MHC限制性的病毒决定簇。
