Robertson David M, Pruysers Enid, Jobling Tom
Prince Henry's Institute of Medical Research, P.O. Box 5152, Clayton, 3168 Vic., Australia.
Cancer Lett. 2007 Apr 28;249(1):14-7. doi: 10.1016/j.canlet.2006.12.017. Epub 2007 Feb 22.
The inhibins are a family of growth factors comprised of several different species that are secreted in the female principally from the ovarian follicle. The inhibins perform best as markers of ovarian cancer when measured collectively (total inhibin) by immunoassays targeted to common epitopes. After menopause with the depletion of ovarian follicles, the circulating level of total inhibin becomes undetectable. In contrast, serum total inhibin levels are elevated in women with ovarian cancer, in particular those with granulosa cell tumours and those with the mucinous subtype of epithelial carcinoma. Investigations into the clinical utility of inhibin to detect ovarian cancer have shown that it complements CA125, an established marker of epithelial ovarian cancer, in that each performs best in detecting different subtypes of ovarian cancer. In some published studies, the two markers together have detected up to 95% of ovarian cancers with 95% specificity.
抑制素是一类生长因子，由几种不同的类型组成，主要在女性体内由卵巢卵泡分泌。当通过针对共同表位的免疫测定法进行总体测量（总抑制素）时，抑制素作为卵巢癌标志物的表现最佳。绝经后，随着卵巢卵泡的耗尽，总抑制素的循环水平变得无法检测到。相比之下，卵巢癌女性的血清总抑制素水平会升高，尤其是那些患有颗粒细胞瘤和黏液性上皮癌亚型的女性。对抑制素检测卵巢癌临床效用的研究表明，它可补充CA125（一种已确立的上皮性卵巢癌标志物），因为两者在检测不同亚型的卵巢癌时各有最佳表现。在一些已发表的研究中，这两种标志物联合使用时，能以95%的特异性检测出高达95%的卵巢癌。
