作为药物应用材料的氢键聚合物间络合物

Hydrogen-bonded interpolymer complexes as materials for pharmaceutical applications.

作者信息

Khutoryanskiy Vitaliy V

机构信息

University of Reading, School of Pharmacy, Whiteknights, PO Box 224, Reading RG6 6AD, UK.

出版信息

Int J Pharm. 2007 Apr 4;334(1-2):15-26. doi: 10.1016/j.ijpharm.2007.01.037. Epub 2007 Feb 2.

DOI:10.1016/j.ijpharm.2007.01.037

PMID:17320317

Abstract

Association of poly(carboxylic acids) and non-ionic polymers in solutions via hydrogen bonding results in formation of novel polymeric materials--interpolymer complexes. These materials can potentially be used for design of novel mucoadhesive dosage forms, development of solid drug dispersions and solubilisation of poorly soluble drugs, encapsulation technologies, preparation of nanoparticles, hydrogels, in situ gelling systems and electrically erodible materials. This review is an attempt to analyse and systematise existing literature on pharmaceutical application of hydrogen-bonded interpolymer complexes.

摘要

通过氢键作用，溶液中的聚羧酸与非离子聚合物缔合形成新型高分子材料——聚合物间复合物。这些材料有可能用于设计新型粘膜粘附剂型、开发固体药物分散体以及增溶难溶性药物、封装技术、制备纳米颗粒、水凝胶、原位凝胶系统和电蚀性材料。本综述旨在分析和整理关于氢键结合聚合物间复合物在药物应用方面的现有文献。