Wang Zeyu, Shui Mingju, Wyman Ian W, Zhang Qing-Wen, Wang Ruibing
State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau Macau 999078 China
Department of Chemistry, Queen's University Kingston ON K7L 3N6 Canada.
RSC Med Chem. 2021 Mar 10;12(5):722-729. doi: 10.1039/d1md00019e. eCollection 2021 May 26.
As a member of the cucurbit[]uril family (where denotes the number of glycoluril units), cucurbit[8]uril (CB[8]) possesses a large cavity volume and is able to accommodate two guests simultaneously. Therefore, CB[8] has been adapted as a dynamic noncovalent crosslinker to form various supramolecular hydrogels. These CB[8]-based hydrogels have been investigated for various biomedical applications due to their good biocompatibility and dynamic properties afforded by host-guest interactions. In this review, we summarize the hydrogels that have been dynamically fabricated supramolecular crosslinking of polymers by CB[8] reported during the past decade, and discuss their design principles, innovative applications in biomedical science and their future prospects.
作为葫芦[n]脲家族的一员（其中n表示甘脲单元的数量），葫芦[8]脲（CB[8]）具有较大的空腔体积，能够同时容纳两个客体。因此，CB[8]已被用作动态非共价交联剂以形成各种超分子水凝胶。由于其良好的生物相容性以及主客体相互作用赋予的动态特性，这些基于CB[8]的水凝胶已被研究用于各种生物医学应用。在本综述中，我们总结了过去十年间报道的通过CB[8]对聚合物进行超分子交联而动态制备的水凝胶，并讨论了它们的设计原理、在生物医学科学中的创新应用及其未来前景。
