Hombach Juliane, Bernkop-Schnürch Andreas
University of Innsbruck, Innrain 52, 6020 Innsbruck, Austria.
Handb Exp Pharmacol. 2010(197):251-66. doi: 10.1007/978-3-642-00477-3_9.
The uptake of drugs is often limited by the short contact time between the formulation and the absorption membrane and by a fast washout. Using mucoadhesive polymers, however, the residence time of the dosage form on the mucosa can be significantly increased. In this chapter the composition of the mucus, the different mucoadhesion theories and binding types between mucus and mucoadhesives, mucoadhesion tests and factors influencing mucoadhesion are introduced. Various mucoadhesive polymers are also described and an overview of various mucoadhesive delivery systems is provided.
药物的吸收常常受到制剂与吸收膜之间接触时间短以及快速清除的限制。然而，使用粘膜粘附聚合物可以显著延长剂型在粘膜上的停留时间。本章介绍了粘液的组成、不同的粘膜粘附理论以及粘液与粘膜粘附剂之间的结合类型、粘膜粘附测试和影响粘膜粘附的因素。还描述了各种粘膜粘附聚合物，并提供了各种粘膜粘附给药系统的概述。
