Shintomi Keishi, Hirano Tatsuya
Cold Spring Harbor Laboratory, 1 Bungtown Road, PO Box 100, Cold Spring Harbor, NY 11724, USA.
Trends Biochem Sci. 2007 Apr;32(4):154-7. doi: 10.1016/j.tibs.2007.02.002. Epub 2007 Feb 21.
The cohesin complex is proposed to embrace sister chromatids within its ring-like structure, in which two ATP-binding 'head' domains of an SMC (structural maintenance of chromosomes) heterodimer are linked by a kleisin subunit. Recent studies shed new light on the crucial functions of the 'hinge' domain of the SMC dimer, which is located approximately 50 nm from the head domains. An emerging idea is that the hinge and head domains cooperatively modulate cohesin-DNA interactions by opening and closing the ring in a highly regulated manner.
黏连蛋白复合体被认为在其环状结构中环绕着姐妹染色单体，其中，染色体结构维持（SMC）异源二聚体的两个ATP结合“头部”结构域通过一个kleisin亚基相连。最近的研究为SMC二聚体“铰链”结构域的关键功能带来了新的认识，该结构域距离头部结构域约50纳米。一个新出现的观点是，铰链结构域和头部结构域通过以高度调控的方式打开和关闭环来协同调节黏连蛋白与DNA的相互作用。
