来自 Cyrneus 肉齿菌的杯伞烷二萜及其神经突生成和神经生长因子产生活性的评估。
Cyathane diterpenes from Sarcodon cyrneus and evaluation of their activities of neuritegenesis and nerve growth factor production.
作者信息
Marcotullio Maria Carla, Pagiotti Rita, Maltese Federica, Oball-Mond Mwankie Gildas Norbert, Hoshino Tomohiro, Obara Yutaro, Nakahata Norimichi
机构信息
Dipartimento di Chimica e Tecnologia del Farmaco-Sez. Chimica Organica, Università degli Studi, 06123 Perugia, Italy.
出版信息
Bioorg Med Chem. 2007 Apr 15;15(8):2878-82. doi: 10.1016/j.bmc.2007.02.019. Epub 2007 Feb 13.
Two new cyathane diterpenes, cyrneine C (4) and D (5), were isolated from the mushroom Sarcodon cyrneus, along with previously isolated cyrneine A, B and glaucopine C. The structures of the novel diterpenoids were determined by the analysis of spectroscopic data. Effects of the cyrneines and glaucopine C on the NGF gene expression in 1321N1 cells and on neurite outgrowth on PC12 cells were evaluated.
从蘑菇 Cyrneomyces cyrneus 中分离出两种新的杯伞烷二萜类化合物，即 Cyrneine C（4）和 D（5），同时还分离出了之前已鉴定的 Cyrneine A、B 和 Glaucopine C。通过光谱数据分析确定了这些新型二萜类化合物的结构。评估了 Cyrneines 和 Glaucopine C 对 1321N1 细胞中 NGF 基因表达以及对 PC12 细胞神经突生长的影响。
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