Division of Biotechnology and Advanced Institute of Environment and Bioscience, College of Environmental and Bioresource Sciences, Jeonbuk National University, Iksan, Korea.
J Antibiot (Tokyo). 2023 Jun;76(6):351-354. doi: 10.1038/s41429-023-00616-z. Epub 2023 Apr 3.
During the search for natural antibiotics from fungal metabolites, a new cyathane diterpenoid, fragilicine A (1), and three known cyathane diterpenoids, erinacines I, A, and B (2-4) were isolated from the culture broth of Dentipellis fragilis. Chemical structures of 1-4 were determined by analyses of 1D- and 2D-NMR and MS data and by comparisons with data of those reported in the literature. These isolated compounds were assessed for their antimicrobial activities against Bacillus subtilis, B. atrophaeus, B. cereus, Listeria monocytogenes, Fusarium oxysporum, Diaporthe sp., and Rhizoctonia solani. These compounds showed weak antimicrobial activities.
在从真菌代谢产物中寻找天然抗生素的过程中，从齿菌属（Dentipellis） fragilis 的发酵液中分离得到了一种新的杯烷二萜类化合物 fragilicine A（1）和三种已知的杯烷二萜类化合物 erinacines I、A 和 B（2-4）。通过对 1D 和 2D-NMR 及 MS 数据的分析以及与文献中报道的数据进行比较，确定了 1-4 的化学结构。这些分离得到的化合物被评估了对枯草芽孢杆菌、萎缩芽孢杆菌、蜡状芽孢杆菌、单核细胞增生李斯特菌、尖孢镰刀菌、胶孢炭疽菌和立枯丝核菌的抗菌活性。这些化合物表现出较弱的抗菌活性。
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