副突变：从玉米到小鼠

Paramutation: from maize to mice.

作者信息

Chandler Vicki L

机构信息

BIO5 Institute and Department of Plant Sciences, University of Arizona, Tucson, AZ 85721, USA.

出版信息

Cell. 2007 Feb 23;128(4):641-5. doi: 10.1016/j.cell.2007.02.007.

DOI:10.1016/j.cell.2007.02.007

PMID:17320501

Abstract

Paramutation is the epigenetic transfer of information from one allele of a gene to another to establish a state of gene expression that is heritable for generations. RNA has recently emerged as a prominent mediator of this remarkable phenomenon in both maize and mice.

摘要

副突变是指基因的一个等位基因的信息发生表观遗传转移至另一个等位基因，从而建立一种可世代遗传的基因表达状态。最近，RNA在玉米和小鼠中已成为这一显著现象的重要介导物。