多梳蛋白和三胸蛋白对基因组的调控

Genome regulation by polycomb and trithorax proteins.

作者信息

Schuettengruber Bernd, Chourrout Daniel, Vervoort Michel, Leblanc Benjamin, Cavalli Giacomo

机构信息

Institute of Human Genetics, CNRS, 141, rue de la Cardonille, 34396 Montpellier Cedex 5, France.

出版信息

Cell. 2007 Feb 23;128(4):735-45. doi: 10.1016/j.cell.2007.02.009.

DOI:10.1016/j.cell.2007.02.009

PMID:17320510

Abstract

Polycomb group (PcG) and trithorax group (trxG) proteins are critical regulators of numerous developmental genes. To silence or activate gene expression, respectively, PcG and trxG proteins bind to specific regions of DNA and direct the posttranslational modification of histones. Recent work suggests that PcG proteins regulate the nuclear organization of their target genes and that PcG-mediated gene silencing involves noncoding RNAs and the RNAi machinery.

摘要

多梳蛋白家族（PcG）和三胸蛋白家族（trxG）蛋白是众多发育基因的关键调节因子。为了分别沉默或激活基因表达，PcG和trxG蛋白会结合到DNA的特定区域，并指导组蛋白的翻译后修饰。最近的研究表明，PcG蛋白调节其靶基因的核组织，并且PcG介导的基因沉默涉及非编码RNA和RNA干扰机制。