Shvarts Iu B, Kahn T G, Pirrotta V
Genetika. 2010 Oct;46(10):1413-6.
The Polycomb (PcG) and Trithorax (TrxG) group proteins are essential for development in all multicellular organisms. Mutations of the PcG and TrxG genes act as early embryonic lethals, while their overexpression correlates with malignancies. Comparative genome analysis showed that PcG and TrxG form a binary regulatory system that functions as an epigenetic rheostat to determine the threshold levels of extracellular signals affecting the expression levels of key developmental genes.
多梳（PcG）蛋白家族和三胸（TrxG）蛋白家族对所有多细胞生物的发育至关重要。PcG和TrxG基因的突变会导致早期胚胎致死，而它们的过表达则与恶性肿瘤相关。比较基因组分析表明，PcG和TrxG形成了一个二元调控系统，该系统作为一种表观遗传变阻器，用于确定影响关键发育基因表达水平的细胞外信号的阈值水平。
