Magaki Shino, Yellon Steven M, Mueller Claudius, Kirsch Wolff M
Center for Neurosurgery Research, Coleman Pavilion, Loma Linda University School of Medicine, Loma Linda, CA 92350, USA.
J Psychiatr Res. 2008 Feb;42(3):240-6. doi: 10.1016/j.jpsychires.2007.01.004. Epub 2007 Feb 23.
Alterations in the peripheral immune system are associated with dementia and the neuropathology of Alzheimer's disease, but have yet to be studied early in the disease process. To test the hypothesis that the balance of immune cell phenotypes is disrupted in the early progression of memory deterioration, patients with mild cognitive impairment (MCI) and healthy elderly controls were examined for the distribution of subpopulations of leukocytes (lymphocytes, granulocytes, and monocytes) and lymphocyte subtypes (helper/inducer and suppressor/cytotoxic T lymphocytes and B lymphocytes) in blood. MCI subjects had a significantly higher percentage of total lymphocytes and a lower percentage of granulocytes compared to elderly controls. Furthermore, the expression of cell surface amyloid precursor protein (APP) and intracellular amyloid-beta peptide (Abeta) in lymphocytes and monocytes were determined. We found lymphocyte APP expression to be significantly increased in MCI subjects compared to controls. Our data indicate that changes in immunological parameters may be detected early in MCI, and an alteration of the immune response may precede clinical AD.
外周免疫系统的改变与痴呆症及阿尔茨海默病的神经病理学相关，但在疾病进程的早期阶段尚未得到研究。为了检验免疫细胞表型平衡在记忆衰退早期进展过程中被破坏这一假说，我们对轻度认知障碍（MCI）患者和健康老年对照者的血液中白细胞亚群（淋巴细胞、粒细胞和单核细胞）及淋巴细胞亚型（辅助/诱导性和抑制/细胞毒性T淋巴细胞以及B淋巴细胞）的分布进行了检测。与老年对照者相比，MCI受试者的总淋巴细胞百分比显著更高，而粒细胞百分比更低。此外，还测定了淋巴细胞和单核细胞中细胞表面淀粉样前体蛋白（APP）及细胞内淀粉样β肽（Aβ）的表达。我们发现，与对照者相比，MCI受试者的淋巴细胞APP表达显著增加。我们的数据表明，在MCI早期即可检测到免疫参数的变化，并且免疫反应的改变可能先于临床AD出现。
