上唇血管平滑肌脂肪瘤：病例报告及文献复习

Angiomyolipoma of the upper lip: case report and review of the literature.

作者信息

da Silva Andréia Aparecida, Carlos Roman, Contreras Elisa, de Almeida Oslei Paes, Lopes Márcio Ajudarte, Vargas Pablo Agustin

机构信息

Department of Oral Diagnosis, Oral Pathology Division, Dental School of Piracicaba, State University of Campinas, Piracicaba, Brazil.

出版信息

Med Oral Patol Oral Cir Bucal. 2007 Mar 1;12(2):E101-4.

PMID:17322795

Abstract

Angiomyolipoma (AML) is a hamartomatous growth that usually affects the kidney. One third of patients with AML present with manifestations of tuberous sclerosis. Oral AML is rare with only 6 cases reported in the English-language literature. In the present case, AML was located in the upper lip of a 43 year-old woman. Clinically, it presented as a firm nodule, well circumscribed and measuring 1 x 2 cm. It was surgically excised. Histopathological analysis showed a lesion composed of an admixture of smooth muscle cells, blood vessels, and adipose tissue. The immunohistochemical study revealed positivity for vimentin, smooth muscle actin, pan specific muscle actin and desmin. CD68, CD34 and mast cell antibodies showed focal immunoreactivity. S100 protein, Ki-67, and HMB-45 were negative. Based on these histological and immunohistochemical features the diagnosis was of oral AML. No recurrence was observed after 2 years of follow-up.

摘要

血管平滑肌脂肪瘤（AML）是一种通常累及肾脏的错构瘤性生长病变。三分之一的AML患者伴有结节性硬化症的表现。口腔AML罕见，英文文献中仅报道过6例。在本病例中，AML位于一名43岁女性的上唇。临床上，它表现为一个质地硬的结节，边界清晰，大小为1×2厘米。该病变通过手术切除。组织病理学分析显示，病变由平滑肌细胞、血管和脂肪组织混合而成。免疫组织化学研究显示波形蛋白、平滑肌肌动蛋白、泛特异性肌动蛋白和结蛋白呈阳性。CD68、CD34和肥大细胞抗体显示局灶性免疫反应性。S100蛋白、Ki-67和HMB-45均为阴性。根据这些组织学和免疫组织化学特征，诊断为口腔AML。随访2年后未观察到复发。