Persson G R, Page R C
Department of Periodontics, University of Washington, Seattle 98195.
J Clin Periodontol. 1992 Jan;19(1):43-8. doi: 10.1111/j.1600-051x.1992.tb01147.x.
During a 2-year period pocket depth, probing attachment level, gingival index, and crevicular fluid aspartate aminotransferase (AST) levels were monitored in 25 previously treated periodontitis patients. Probing attachment level change was used retrospectively to identify sites where active periodontal destruction had occurred. The ability of crevicular fluid AST activities at 600, 800, 1000, and 1200 microIU levels to recognize active disease was investigated. Probing attachment level changes observed support the concept that the pattern of periodontal disease activity is episodic and infrequent. A loss of greater than or equal to 2 mm was found at 11% of all studied sites, whereas a gain of greater than or equal to 2 mm was noticed for 15% of sites. 2 subjects had 3 teeth that lost greater than or equal to 2 mm of attachment, whereas 15 subjects demonstrated no teeth with disease activity. The remaining 8 subjects had 1 or 2 sites that lost greater than or equal to 2 mm of attachment. Bayes's theorem and ROC curves were used to exemplify the sensitivity and the specificity of AST assessments. The AST 800 microIU demonstrated a sensitivity of 0.93 and specificity 0.68 and an odds ratio of 15.4 for attachment loss greater than or equal to 2 mm. Under the conditional probability of either 50%, 25% or 10% active disease prevalence, AST 800 microIU has a predictability of 73%, 50% and 24% respectively.
在2年的时间里，对25名既往接受过治疗的牙周炎患者的牙周袋深度、探诊附着水平、牙龈指数和龈沟液天冬氨酸转氨酶（AST）水平进行了监测。回顾性地利用探诊附着水平的变化来确定发生活动性牙周破坏的部位。研究了龈沟液AST活性在600、800、1000和1200微国际单位水平识别活动性疾病的能力。观察到的探诊附着水平变化支持了牙周疾病活动模式是间歇性且不频繁的这一概念。在所有研究部位中，11%的部位附着丧失大于或等于2毫米，而15%的部位附着增加大于或等于2毫米。2名受试者有3颗牙齿附着丧失大于或等于2毫米，而15名受试者没有牙齿出现疾病活动。其余8名受试者有1个或2个部位附着丧失大于或等于2毫米。使用贝叶斯定理和ROC曲线来举例说明AST评估的敏感性和特异性。对于附着丧失大于或等于2毫米，AST 800微国际单位的敏感性为0.93，特异性为0.68，比值比为15.4。在活动性疾病患病率为50%、25%或10%的条件概率下，AST 800微国际单位的预测性分别为73%、50%和24%。
