Iglesias Javier, Villa Alessandro E P
Inserm, U318, Laboratoire de Neurobiophysique, Université Joseph Fourier, Grenoble 1, CHU Michallon Pavillon B, BP 217, F-38043 Grenoble Cedex, France.
Biosystems. 2007 May-Jun;89(1-3):287-93. doi: 10.1016/j.biosystems.2006.05.020. Epub 2006 Nov 15.
Adult patterns of neuronal connectivity develop from a transient embryonic template characterized by exuberant projections to both appropriate and inappropriate target regions in a process known as synaptic pruning. Trigger signals able to induce synaptic pruning could be related to dynamic functions that depend on the timing of action potentials. We stimulated locally connected random networks of spiking neurons and observed the effect of a spike-timing-dependent synaptic plasticity (STDP)-driven pruning process on the emergence of cell assemblies. The spike trains of the simulated excitatory neurons were recorded. We searched for spatiotemporal firing patterns as potential markers of the build-up of functionally organized recurrent activity associated with spatially organized connectivity.
成人神经元连接模式从短暂的胚胎模板发育而来，该模板的特征是在一个被称为突触修剪的过程中，向合适和不合适的目标区域都有丰富的投射。能够诱导突触修剪的触发信号可能与依赖于动作电位时间的动态功能有关。我们刺激了局部连接的随机发放神经元网络，并观察了一种依赖于发放时间的突触可塑性（STDP）驱动的修剪过程对细胞集合体出现的影响。记录了模拟兴奋性神经元的发放序列。我们寻找时空发放模式，作为与空间组织连接性相关的功能组织化循环活动建立的潜在标志物。
