Pfütze Martin, Niedermeier Andrea, Hertl Michael, Eming Rüdiger
Department of Dermatology and Allergology, Philipps-University, Marburg, Deutschhausstrasse 9, 35037 Marburg, Germany.
Eur J Dermatol. 2007 Jan-Feb;17(1):4-11. doi: 10.1684/ejd.2007.0090. Epub 2007 Feb 27.
At present, there is no consensus about the clinical criteria that define disease severity of pemphigus. During recent years several scoring systems have been introduced which mainly compare inter-individual differences in disease activity. It thus remains a challenge to reflect the disease activity of individual patients by a standardised scoring system. Due to the remarkable clinical variability of pemphigus, several parameters are needed to reflect phenotypical varieties of this severe autoimmune bullous skin disorder. In view of the evaluation of different therapeutic options a scoring system sensitive enough to reflect gradual changes in disease activity seems more appropriate than a grading system for inter-individual comparison of disease severity. Taking this challenge into account we introduce and discuss a newly developed autoimmune bullous skin disorder intensity score (ABSIS).
目前，对于定义天疱疮疾病严重程度的临床标准尚无共识。近年来，已经引入了几种评分系统，这些系统主要比较疾病活动度的个体间差异。因此，用标准化评分系统反映个体患者的疾病活动度仍然是一项挑战。由于天疱疮具有显著的临床变异性，需要多个参数来反映这种严重自身免疫性大疱性皮肤病的表型多样性。鉴于对不同治疗方案的评估，一个足够敏感以反映疾病活动度逐渐变化的评分系统似乎比用于个体间疾病严重程度比较的分级系统更为合适。考虑到这一挑战，我们引入并讨论一种新开发的自身免疫性大疱性皮肤病强度评分（ABSIS）。
