Niebuhr Margarete, Völker Bernward, Kapp Alexander, Wedi Bettina
Department of Dermatology and Allergology, Hannover Medical University, Ricklinger Str. 5, D-30449 Hannover, Germany.
Eur J Dermatol. 2007 Jan-Feb;17(1):89-91. doi: 10.1684/ejd.2007.0195. Epub 2007 Feb 27.
Neutrophilic panniculitis (NP) is a widely unknown inflammatory disorder of the subcutaneous fat. The diagnosis and proper classification of panniculitis relies on histologic features, mainly the location of the subcutaneous inflammation (septal, lobular, mixed or vascular). In contrast to erythema nodosum, where the inflammation predominates in the fat septa, NP is localized in the fat lobules. However, little is known about this rare condition. We report a 54-year-old woman with a history of several episodes with subcutaneous nodules occurring on the lower legs secondary to bacterial cystitis (successfully treated with antibiotics prior to admission to our Department), that responded immediately to treatment with oral corticosteroids. An infective aetiology for NP has not been described so far, although this can be found in other neutrophilic dermatoses. The originality of our case is the recurrence of the disease on several occasions in association with bacterial cystitis. This case confirms that infections can be a cause of NP.
中性粒细胞性脂膜炎（NP）是一种鲜为人知的皮下脂肪炎症性疾病。脂膜炎的诊断和正确分类依赖于组织学特征，主要是皮下炎症的部位（间隔性、小叶性、混合性或血管性）。与结节性红斑不同，结节性红斑的炎症主要在脂肪间隔中，而NP则局限于脂肪小叶。然而，对于这种罕见病症人们了解甚少。我们报告一名54岁女性，有多次小腿出现皮下结节的病史，继发于细菌性膀胱炎（在入住我们科室之前已用抗生素成功治疗），口服糖皮质激素治疗后症状立即缓解。虽然在其他中性粒细胞性皮肤病中可发现感染病因，但迄今为止尚未有NP感染病因的描述。我们病例的独特之处在于该疾病多次复发并伴有细菌性膀胱炎。该病例证实感染可能是NP的一个病因。
