Lehmann B V, Oberdisse E, Grajewski O, Arntz H R
Arch Toxicol. 1975 Oct 20;34(2):89-101. doi: 10.1007/BF00353309.
After intravenous injection of praseodymium nitrate, female Wistar rats develop fatty livers. In contrast to the marked increase of triglycerides, the phospholipid content was only increased by 50%. The subcellular distribution of phospholipids showed that major changes occur in the microsomal fraction within the first 24 hrs. Among the individual phospholipids only phosphatidylcholine and phosphatidylethanolamine concentrations were elevated. Further subfractioning revealed that phospholipid concentration increased in the smooth endoplasmic reticulum, whereas it decreased in the rough endoplasmic reticulum. The individual phospholipids in the smooth endoplasmic reticulum increased to the same degree as did the total phospholipids. On the other hand, in the rough endoplasmic reticulum only the lecithin fraction decreased, while all other phospholipids remained unchanged. Cytochrome P450, cytochrome b5, and glucose 6-phosphatase activity were drastically reduced in the rough endoplasmic reticulum, while no changes could be observed in the smooth endoplasmic reticulum. In the serum, phospholipid concentration fell to half the normal value within the first 24 hrs after praseodymium intoxication.
静脉注射硝酸镨后，雌性Wistar大鼠会出现脂肪肝。与甘油三酯显著增加形成对比的是，磷脂含量仅增加了50%。磷脂的亚细胞分布表明，主要变化发生在微粒体部分，且在前24小时内最为明显。在各个磷脂中，只有磷脂酰胆碱和磷脂酰乙醇胺的浓度升高。进一步的亚分级显示，光滑内质网中的磷脂浓度增加，而粗面内质网中的磷脂浓度降低。光滑内质网中的各个磷脂增加的程度与总磷脂相同。另一方面，在粗面内质网中，只有卵磷脂部分减少，而其他所有磷脂保持不变。粗面内质网中的细胞色素P450、细胞色素b5和葡萄糖6-磷酸酶活性急剧降低，而光滑内质网中未观察到变化。在血清中，镨中毒后的前24小时内，磷脂浓度降至正常值的一半。
