Imbert M, Nguyen D, Sultan C
Laboratory of Hematology-Immunology, Henri Mondor Hospital, Creteil, France.
Leuk Res. 1992;16(1):51-4. doi: 10.1016/0145-2126(92)90100-l.
Acute myeloid leukemias (AML) and myelodysplastic syndromes (MDS) enter rarely in the differential diagnosis of myelofibrosis (MF). MF of marked intensity, resulting in either "dry taps" or non-representative smears, is encountered in approximately 10% of cases. MF may be observed in any type of AML, most frequently in acute megakaryoblastic leukemia (M7). Apart from some typical cases of MDS, MF is associated with cases of acute myelodysplasia with myelofibrosis (and a major megakaryocytic component). This syndrome has been described under various headings: acute or malignant myelosclerosis, and acute MF. It should be distinguished from M7 and from myeloproliferative syndromes.
急性髓系白血病（AML）和骨髓增生异常综合征（MDS）很少纳入骨髓纤维化（MF）的鉴别诊断。约10%的病例会出现显著强度的MF，导致“干抽”或非代表性涂片。MF可见于任何类型的AML，最常见于急性巨核细胞白血病（M7）。除了一些典型的MDS病例外，MF还与伴有骨髓纤维化的急性骨髓发育异常（以及主要的巨核细胞成分）病例相关。该综合征曾有多种命名：急性或恶性骨髓硬化症以及急性MF。它应与M7和骨髓增殖性综合征相鉴别。
