Yahata N, Ohyashiki K, Iwase O, Kimura Y, Kodama A, Fukutake K, Toyama K
First Department of Internal Medicine, Tokyo Medical College, Japan.
Leuk Res. 1998 Sep;22(9):845-7. doi: 10.1016/s0145-2126(98)00019-8.
We report the second case of post-myelodysplasia acute myeloid leukemia (post-MDS AML) with a sole chromosome change del(15q). This anomaly is rarely seen. To our knowledge, only seven cases so far have been reported in human neoplasias, including one case each of acute myeloid leukemia (AML), acute lymphoid leukemia, post myelodysplasia AML, myelodysplastic syndrome, myelofibrosis, macroglobulinemia, Hodgkin's lymphoma and uterine leiomyoma. This case suggests that del(15q) is related to lympho-myeloproliferative disorders. Moreover, we speculate that certain oncogene(s) located on 15q might have some role in the progression of the disease, since the del(15q) anomaly appeared only in the AML phase in this case.
我们报告了第二例骨髓增生异常综合征后急性髓系白血病（post-MDS AML），其仅有染色体改变del(15q)。这种异常很少见。据我们所知，迄今为止在人类肿瘤中仅报道过7例，包括急性髓系白血病（AML）、急性淋巴细胞白血病、骨髓增生异常综合征后AML、骨髓增生异常综合征、骨髓纤维化、巨球蛋白血症、霍奇金淋巴瘤和子宫平滑肌瘤各1例。该病例提示del(15q)与淋巴-骨髓增殖性疾病有关。此外，我们推测位于15q上的某些癌基因可能在疾病进展中起一定作用，因为在该病例中del(15q)异常仅出现在AML阶段。
