Kim Hee Man, Park Jong, Ryu So Yeon, Kim Jongoh
Korean Association of Public Health Doctor, Chungcheongbuk-do, Korea.
Diabetes Care. 2007 Mar;30(3):701-6. doi: 10.2337/dc06-1400.
This study examined the effect of menopausal status on the risk of the metabolic syndrome in Korean women.
Data were obtained from the Korean National Health and Nutrition Examination Survey of 2001. A total of 2,671 women who did not receive hormone replacement therapy (1,893 premenopausal women and 778 postmenopausal women) were included in the analysis. The metabolic syndrome was defined according to the National Cholesterol Education Program Adult Treatment Panel III.
Postmenopausal women had significantly higher mean waist circumference, systolic blood pressure, pulse pressure, total cholesterol, LDL cholesterol, and triglyceride levels than premenopausal women after adjusting for age (P = 0.018, P = 0.001, P < 0.0001, P < 0.0001, P < 0.0001, and P = 0.006, respectively). Among postmenopausal women, the age-adjusted odds ratio was 1.61 (95% CI 1.15-2.25) for abdominal obesity, 1.11 (0.76-1.61) for elevated blood pressure, 1.24 (0.90-1.72) for low HDL cholesterol, 1.28 (0.89-1.83) for high triglycerides, and 1.07 (0.69-1.65) for high fasting glucose compared with premenopausal women. The multivariate-adjusted odds ratio for the metabolic syndrome was 1.60 (95% CI 1.04-2.46) among postmenopausal women compared with premenopausal women.
Postmenopausal status is associated with an increased risk of the metabolic syndrome independent of normal aging in Korean women.
本研究调查了绝经状态对韩国女性代谢综合征风险的影响。
数据来自2001年韩国全国健康与营养检查调查。共有2671名未接受激素替代疗法的女性（1893名绝经前女性和778名绝经后女性）纳入分析。代谢综合征根据美国国家胆固醇教育计划成人治疗小组第三次报告进行定义。
在调整年龄后，绝经后女性的平均腰围、收缩压、脉压、总胆固醇、低密度脂蛋白胆固醇和甘油三酯水平显著高于绝经前女性（P分别为0.018、0.001、<0.0001、<0.0001、<0.0001和0.006）。在绝经后女性中，与绝经前女性相比，年龄调整后的腹部肥胖比值比为1.61（95%可信区间1.15 - 2.25），高血压为1.11（0.76 - 1.61），低高密度脂蛋白胆固醇为1.24（0.90 - 1.72），高甘油三酯为1.28（0.89 - 1.83），高空腹血糖为1.07（0.69 - 1.65）。与绝经前女性相比，绝经后女性代谢综合征的多变量调整比值比为1.60（95%可信区间1.04 - 2.46）。
在韩国女性中，绝经状态与代谢综合征风险增加相关，且独立于正常衰老。
