Galogre A G, Gorgoshidze G G, Dgebuadze M A, Mosidze T G
Georgian Med News. 2007 Jan(142):50-4.
The indices of the mitotic activity, the quantity of the double-nucleated cells and the dying nucleus coefficient in the basal and spinous layers of the rat multilayer flat epithelium after the extraction a tooth were studied. The experiments were carried out on 45 nonlinear white mature rats - males. After peeling the gingiva around the dental neck we extract three basal teeth. In the epithelial regenerates we counted amount of the mitotic figures (prophase, metaphase, anaphase, telophase) in the basal and spinous cells, double-nucleated cells in the spinous layer and the number of the dying nucleus (picnosis, karyolisis) among 5 000 cells. It was established that the tissue defect was filled up owing to the intensification of the mitotic activity in the germinative layer, namely, dew new cells generation. In spite of the rise the quantity of dying nucleus, the number of the dividing cells exceeds the number of the dying owns, what provides the reparation of the multilayer flat gingival epithelium in the region of the wound.
研究了拔牙后大鼠复层扁平上皮基底层和棘层的有丝分裂活性指标、双核细胞数量及核固缩系数。实验选用45只成年雄性非线性白色大鼠。在牙颈部周围牙龈剥离后，拔除三颗基牙。在上皮再生组织中，计数基细胞和棘细胞中有丝分裂象（前期、中期、后期、末期）的数量、棘层中双核细胞的数量以及5000个细胞中核固缩（核固缩、核溶解）的数量。结果表明，由于生发层有丝分裂活性增强，即新细胞生成，组织缺损得以填充。尽管核固缩数量增加，但分裂细胞的数量超过了死亡细胞的数量，这为伤口区域复层扁平牙龈上皮的修复提供了保障。
