Room temperature zinc chloride-catalyzed cycloisomerization of Alk-3-yn-1-ones: synthesis of substituted furans.
作者信息
Sniady Adam, Durham Audrey, Morreale Marco S, Wheeler Kraig A, Dembinski Roman
机构信息
Department of Chemistry, Oakland University, Rochester, MI 48309-4477, USA.
出版信息
Org Lett. 2007 Mar 29;9(7):1175-8. doi: 10.1021/ol062539t. Epub 2007 Mar 1.
PMID:17328552
Abstract
[structure: see text]. 5-Endo-dig cycloisomerization of 1,4-di- and 1,2,4-trisubstituted but-3-yn-1-ones in the presence of a catalytic amount of zinc chloride (10 mol %) in dichloromethane at room temperature (22 degrees C) provides 2,5-di- and 2,3,5-trisubstituted furans in high yields (85-97%).
摘要
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