Sandras Raphael, Lesaffre Francois, Lacotte Jérome, Nazeyrollas Pierre
Département de Cardiologie et Pathologies Vasculaires, CHU, Reims.
Presse Med. 2007 Apr;36(4 Pt 1):612-4. doi: 10.1016/j.lpm.2006.11.028. Epub 2007 Feb 27.
The Brugada syndrome is a rare genetic disease that can lead to death. Its diagnosis requires electrocardiography.
A 36-year-old man was admitted with syncope. Brugada syndrome was diagnosed by the typical ECG pattern. The interaction between lithium therapy and ECG was shown clearly by the alternating type 1 and type 3 Brugada ECG patterns, depending on lithium status.
The Brugada syndrome may be unmasked by lithium therapy, due to its properties as a Na+ channel blocker, even at low doses. This case also demonstrated the usefulness of ECG in detecting the Brugada syndrome before and during lithium prescription.
布加综合征是一种可导致死亡的罕见遗传病。其诊断需要进行心电图检查。
一名36岁男性因晕厥入院。通过典型的心电图模式诊断为布加综合征。根据锂的状态，1型和3型布加综合征心电图模式交替出现，清楚地显示了锂治疗与心电图之间的相互作用。
由于锂作为一种钠通道阻滞剂的特性，即使在低剂量时，锂治疗也可能使布加综合征显现出来。该病例还证明了心电图在锂治疗前和治疗期间检测布加综合征的有用性。
