Cailhol Johann, Bouchaud Olivier
Consultation du Voyage et de Médecine Tropicale, Hôpital Avicenne, Bobigny.
Presse Med. 2007 Apr;36(4 Pt 2):717-22. doi: 10.1016/j.lpm.2007.01.024. Epub 2007 Feb 27.
Travelers' diarrhea is an important health concern for travelers, with an attack rate of approximately 40%. Except in the elderly or young children, who may have severe cases, travelers' diarrhea is usually mild but can lead to significant discomfort and to chronic forms. Bacteria, especially enterotoxinogenic E. coli, are its principal causes. Unsafe solid food is, even more than water, its main vector. Quinolones and azithromycin are very effective but rehydration remains the cornerstone of treatment. Quinolones can be used for preventive treatment but only for travelers at high risk. Other means of prevention include food hygiene, although its effectiveness is limited. More useful than forbidding foods is counseling travelers to wash their hands and eat safe food (cooked, hot). Preventive nonabsorbed antiinfective agents and vaccination against enterotoxinogenic E. coli should be available relatively soon and will decrease the incidence of travelers' diarrhea.
旅行者腹泻是旅行者关注的重要健康问题,发病率约为40%。除了可能出现严重病例的老年人或幼儿外,旅行者腹泻通常症状较轻,但可能导致明显不适并发展为慢性形式。细菌,尤其是产肠毒素大肠杆菌,是其主要病因。不安全的固体食物甚至比水更是其主要传播媒介。喹诺酮类和阿奇霉素非常有效,但补液仍然是治疗的基石。喹诺酮类可用于预防性治疗,但仅适用于高危旅行者。其他预防手段包括食品卫生,尽管其效果有限。比禁食食物更有用的是建议旅行者洗手并食用安全的食物(煮熟、热的)。预防性非吸收性抗感染药物和产肠毒素大肠杆菌疫苗应很快就能问世,这将降低旅行者腹泻的发病率。