Daniels Derek, Yee Daniel K, Fluharty Steven J
Department of Psychology, State University of New York at Buffalo, Buffalo, NY 14260, USA.
Exp Physiol. 2007 May;92(3):523-7. doi: 10.1113/expphysiol.2006.036897. Epub 2007 Feb 28.
Angiotensin II plays a key role in the regulation of body fluid homeostasis. To correct body fluid deficits that occur during hypovolaemia, an animal needs to ingest both water and electrolytes. Thus, it is not surprising that angiotensin II, which is synthesized in response to hypovolaemia, acts centrally to increase both water and NaCl intake. Here, we review findings relating to the properties of angiotensin II receptors that give rise to changes in behaviour. Data are described to suggest that divergent signal transduction pathways are responsible for separable behavioural responses to angiotensin II, and a hypothesis is proposed to explain how this divergence may map onto neural circuits in the brain.
血管紧张素II在体液平衡调节中起关键作用。为纠正低血容量期间出现的体液不足，动物需要摄入水和电解质。因此，因低血容量而合成的血管紧张素II在中枢起作用以增加水和氯化钠的摄入量也就不足为奇了。在此，我们综述了与血管紧张素II受体特性相关的研究结果，这些特性会引起行为变化。所描述的数据表明，不同的信号转导途径负责对血管紧张素II的可分离行为反应，并提出了一个假设来解释这种差异如何映射到大脑中的神经回路。
