Behavioral Neuroscience Program, Department of Psychology, The State University of New York at Buffalo, SUNY, Buffalo, New York 14260, USA.
Physiol Behav. 2010 Jul 14;100(5):496-502. doi: 10.1016/j.physbeh.2010.03.012. Epub 2010 Mar 25.
Understanding the role of intracellular signaling pathways in ingestive behavior is a challenging problem in behavioral neuroscience. This review summarizes work conducted on two systems with the aim of identifying intracellular events that relate to food and fluid intake. The first set of experiments focused on melanocortin receptors and their ability to signal through members of the mitogen-activated protein (MAP) kinase family. The second set of experiments focused on the role of intracellular signaling pathways in water and saline intakes that are stimulated by angiotensin II (AngII). The initial findings in each line of research have been extended by subsequent research that is discussed in turn. The paper represents an invited review by a symposium, award winner or keynote speaker at the Society for the Study of Ingestive Behavior [SSIB] Annual Meeting in Portland, July 2009.
理解细胞内信号通路在摄食行为中的作用是行为神经科学中的一个难题。这篇综述总结了在两个系统上进行的工作，旨在确定与食物和液体摄入相关的细胞内事件。第一组实验集中在黑皮质素受体及其通过丝裂原活化蛋白激酶（MAPK）家族成员信号转导的能力上。第二组实验集中在细胞内信号通路在血管紧张素 II（AngII）刺激的水和盐水摄入中的作用上。在每一行研究的初始发现已经被随后的研究扩展，这些研究将依次讨论。本文是 2009 年 7 月在波特兰举行的摄食行为学会（SSIB）年会上的一个专题讨论、获奖者或主题演讲的特邀评论。
